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Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds.
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Specifiche
| Razza | |
|---|---|
| Gene | |
| Cromosoma | 10 |
| Mutation | exon 2 deletion in the COMMD1 gene |
| Tipo di Ereditarietà | Autosomico Recessivo |
| Organo | |
| Campione | Tampone, Sangue in EDTA, Sangue in Eparina, Seme, Tessuto |
| Also known as | Wilson disease |
Informazioni generali
Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds. A dog that retains too much copper from its diet suffers from copper toxicosis, which causes liver damage and associated negative effects.
In the Bedlington Terrier, a recessive mutation to the gene COMMD1 (also known as MURR1) is known to cause elevated copper levels, resulting in copper toxicosis.
Caratteristiche cliniche
I segni clinici di danno epatico a seguito di tossicosi da rame possono includere fegato infiammato, anoressia, vomito, letargia, perdita di peso, ittero e addome gonfio.
La tossicosi da rame può essere mitigata con una dieta specializzata a basso contenuto di rame e ad alto contenuto di zinco.
Informazioni aggiuntive
Although copper toxicosis in Bedlington Terriers was historically caused by a mutation in COMMD1, selection against this mutation has greatly reduced its prevalence in the breed. However, the ATP7B mutation was already present at low frequency and appears to have been inadvertently selected for. As a result, the ATP7B mutation is now more common than in the past and is responsible for most cases of copper toxicosis in modern Bedlington Terriers.
Riferimenti
Pubmed ID: 16293123
Year published: 2005
Omia ID: 1988
Omia variant ID: 643