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Piebald – the presence of white spots or splotches on the coat – is caused by a mutation to the MITF gene, known commonly as the S-Locus (‘Spotting’ locus).
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Specifiche
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informazioni generali
Piebald – the presence of white spots or splotches on the coat – is caused by a mutation to the MITF gene, known commonly as the S-Locus (‘Spotting’ locus). The mutation is dominant, and a dog carrying at least one copy of the mutant allele will show some degree of white spotting.
Caratteristiche cliniche
Absence/reduction of melanocytes results in various degrees of white spotting, from tiny white spots up to completely white animals.
Informazioni aggiuntive
Coat colour is an intricate trait that involves a combination of multiple different genes. Testing for a range of different loci will give the most complete prediction of a dog's coat colour genetics.
Specific breeds are undefined.
Riferimenti
Pubmed ID: 17906626
Omia ID: 214
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