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Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds.
Working days 10
Specifiche
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Tampone, Sangue in EDTA, Sangue in Eparina, Seme, Tessuto |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informazioni generali
Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds. A dog that retains too much copper from its diet suffers from copper toxicosis, which causes liver damage and associated negative effects.
In the Bedlington Terrier, a recessive mutation to the gene COMMD1 (also known as MURR1) is known to cause elevated copper levels, resulting in copper toxicosis.
While copper toxicosis also occurs in breeds such as the Doberman and Labrador Retriever, the disorder in those breeds is caused by a mutation to another gene, ATP7B.
Caratteristiche cliniche
I segni clinici di danno epatico a seguito di tossicosi da rame possono includere fegato infiammato, anoressia, vomito, letargia, perdita di peso, ittero e addome gonfio.
La tossicosi da rame può essere mitigata con una dieta specializzata a basso contenuto di rame e ad alto contenuto di zinco.
Informazioni aggiuntive
Con le relazioni attuali non si può affermare che la cancellazione nel gene COMMD1 sia l'unica causa di tossicosi del rame.
Riferimenti
Pubmed ID: 16293123
Omia ID: 1988