Dystrophic Epidermolysis Bullosa (RDEB) – Central Asian Shepherd

Epidermolysis Bullosa (EB, also called Ectodermal Dysplasia, Butterfly Disease or Skin Fragility Syndrome) is a severe tissue disorder that results in hair loss and in extremely fragile skin. Euthanasia is usually required for affected dogs. This variant, known as (Recessive) Dystrophic Epidermolysis Bullosa (RDEB), is caused by a recessive mutation to the gene COL7A1. It is found in the Central Asian Shepherd Dog. Related variants are also found in the Golden Retriever and Basset Hound.