Gangliosidosis (GM2, Sandhoff Disease) – Shiba Inu

Gangliosidosis is a type of metabolic disorder that affects the muscles and nervous system, causing progressive dysfunction and impaired growth. This form of the disorder analysed in this test, known as GM2 Gangliosidosis variant 0 or as Sandhoff Disease, is caused by a recessive mutation to the gene HEXB. This variant is found in the Shiba Inu. A related variant has also been observed in the Toy Poodle. The disorder is progressive and severe.