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H777

Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder of the footpads, which causes the development of thick, painful, callus-like growths.

Working days 10

Specifiche

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Also known as

Year Published

Informazioni generali

Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder of the footpads, which causes the development of thick, painful, callus-like growths. This variant of the disorder, found in the Rottweiler, is caused by a recessive mutation to the gene DSG1. The disorder is also known as Palmoplantar Hyperkeratosis.

Caratteristiche cliniche

Symptoms for HFH affected dogs start at about 8 weeks of age, with footpads appearing unusually dry. The pads develop thick, rapidly-growing horny growths, which are painful and can cause additional discomfort while standing. The condition may also leave the dog more susceptible to additional skin and ear infections.

Informazioni aggiuntive

Riferimenti

Pubmed ID: 32344723

Omia ID: 2266

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