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H988

Hereditary Necrotising Myelopathy (HNM) is a degenerative neural disease that causes difficulty standing, walking and eating.

Working days 10

Specifiche

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Also known as

Year Published

Informazioni generali

Hereditary Necrotising Myelopathy (HNM) is a degenerative neural disease that causes difficulty standing, walking and eating. The disorder is found in the Dutch Kooiker and is caused by a recessive mutation to the gene IBA57.

Caratteristiche cliniche

Affected dogs generally start displaying symptoms at approximately 4 years of age, though individual cases can start as early as 6 months or as late as 10 years. Symptoms of HNM include difficulty getting up and standing, a stiff and sometimes painful gait, muscle weakness, difficulty eating and drinking, excessive drooling, anorexia, depression and an altered voice.

Informazioni aggiuntive

Riferimenti

Pubmed ID: 37588046

Omia ID: 706

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