Junctional Epidermolysis Bullosa (JEB, LAMA3-related) – German Pointer

Epidermolysis Bullosa (EB, also called Ectodermal Dysplasia or Skin Fragility Syndrome) is a severe tissue disorder that results in hair loss and in extremely fragile skin. Euthanasia is usually required for affected dogs. The specific version of the disease analysed in this test, known as Junctional Epidermolysis Bullosa (JEB), is caused by a recessive mutation to the gene LAMA3. This variant is found in the German Shorthaired Pointer. A closely related variant is also found in the Australian Cattle Dog.