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Multidrug Resistance 1 (MDR1), sometimes known as Ivermectin Sensitivity, is a disorder that affects the blood-brain barrier.
Working days 10
Specifiche
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specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
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Chromosome | |
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Informazioni generali
Multidrug Resistance 1 (MDR1), sometimes known as Ivermectin Sensitivity, is a disorder that affects the blood-brain barrier. As a result, affected animals can be in effect poisoned when given certain drugs as part of standard veterinary procedures. In cats, a variant of the disease is caused by a recessive mutation to the gene ABCB1.
It is estimated that this mutation occurs in approximately 4% of domestic cats.
Caratteristiche cliniche
Affected cats are likely to experience adverse reactions (central nervous system toxicity) to P-glycoprotein substrate drugs such as ivermectin, imidacloprid and selamectin.
Informazioni aggiuntive
Riferimenti
Pubmed ID: 25660379
Omia ID: 1402