MDR1 Multi Drug Resistance – Phenobarbital Resistance (Border Collie)

Multidrug Resistance (MDR) is a disorder that affects P-glycoprotein, an important part of the blood-brain barrier. This can result in certain drugs being ineffective or even dangerous to affected dogs. The variant of MDR analysed in this test decreases the effectiveness of phenobarbital treatment for epilepsy. The variant occurs in the Border Collie, and is caused by an incompletely dominant mutation to the gene ABCB1.