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Multidrug resistance 1 (MDR1), also called Ivermectin Sensitivity, is a defect in the blood-brain barrier that can cause an adverse reaction to certain drugs.
Working days 10
Specifiche
| Breeds | Australian Shepherd – Cane Pastore Australiano, Bobtail – Old English Sheepdog, Cane da pastore tedesco, Collie Ruvido, Smooth Collie (Cane da pastore a pelo corto), Border Collie, Shetland Sheepdog, Whippet |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informazioni generali
Multidrug resistance 1 (MDR1), also called Ivermectin Sensitivity, is a defect in the blood-brain barrier that can cause an adverse reaction to certain drugs. It is caused by a mostly recessive mutation to the ABCB1 (MDR1) gene.
Caratteristiche cliniche
La neurotossicità dopo somministrazione del farmaco, che varia in base alla dose, è il segno principale. I cani possono mostrare atassia, tremori, convulsioni, salivazione eccessiva, otttundazione, bradicardia, midriasi, perdita di minaccia, perdita di risposte alla luce papillare, coma e arresto respiratorio.
Informazioni aggiuntive
This test is based on an association study.
This disorder is noted as recessive. However, in some cases, carriers of the mutation have been observed to present with a milder form of the disorder.
Riferimenti
Pubmed ID: 11692082
Omia ID: 1402
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