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Musladin-Lueke Syndrome is a heritable disease specific to Beagles which causes tightened skin, stiff joints and a “ballerina”-like tip-toed gait.
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Specifiche
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informazioni generali
Musladin-Lueke Syndrome is a heritable disease specific to Beagles which causes tightened skin, stiff joints and a “ballerina”-like tip-toed gait. Originally called Chinese Beagle Syndrome, it was renamed after prolific Beagle breeders Anton Musladin and Ada Lueke. It is a recessive disorder, caused by a defective ADAMTSL2 gene.
Caratteristiche cliniche
Affected dogs are short, with thick and tight skin, severely restricted joint mobility, and the tendency to walk on the very tips of their toes. They develop distinctive, unusually broad heads, with wide-set slanted eyes and creased ears. Heart disease may also be associated with the condition.
Informazioni aggiuntive
Riferimenti
Pubmed ID: 20862248
Omia ID: 1509