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Neuronal Ceroid Lipofuscinosis (NCL) is the name referring to a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death.
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Specifiche
| Razza | |
|---|---|
| Organo | |
| Gene | |
| Campione | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Tipo di Ereditarietà | Autosomal Recessive |
| Cromosoma | 22 |
| Tipo di Ereditarietà | NCL5 |
| Anno di pubblicazione |
Informazioni generali
Neuronal Ceroid Lipofuscinosis (NCL) is the name referring to a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. This variant, occurring in the Golden Retriever, is the result of a recessive mutation to the CLN5 gene. A similar mutation also occurs in the Australian Cattle Dog and Border Collie.
Caratteristiche cliniche
Onset of NCL in the Golden Retriever occurs at about 15 months of age. Symptoms include ataxia (loss of coordination), anxiety, pacing/circling, tremors, aggression, visual impairment and seizures.
Informazioni aggiuntive
Riferimenti
Pubmed ID: 25934231
Omia ID: 1482