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Polycystic Kidney Disease (PKD) occurs frequently in cats.
Working days 10
Specifiche
| Breeds | Americano a pelo corto (American shorthair), Birmano, Burmilla, Chinchilla Cat, Exotic Shorthair, Himalayan, Inglese a pelo corto (British Shorthair), Inglese a pelo lungo (British Longhair), Persiano, Selkirk Rex, Ragdoll, Scottish fold |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informazioni generali
Polycystic Kidney Disease (PKD) occurs frequently in cats. During the life of an affected cat, cysts appear in the kidneys. These cysts put pressure on the healthy kidney tissue, which leads to a loss of function of the affected kidneys.
The disease is caused by a dominant mutation to the gene PKD1, and occurs primarily in Persian cats and Persian-related breeds, but also in breeds such as the American Shorthair, Muchkin and Scottish Fold. The mutation is likely homozygous lethal, meaning that matings between carriers can only result in either carriers (heterozygous) or unaffected cats, not fully affected (homozygous) cats.
Caratteristiche cliniche
Polycystic Kidney Disease causes progressive loss of kidney function. The symptoms become apparent at an adult age. Symptoms are loss of appetite, excessively drinking and urinating, vomiting, lethargy and otherwise altered behaviour.
Mating two carriers may result in a smaller litter size, as homozygous (affected) embryos spontaneously abort.
Informazioni aggiuntive
Riferimenti
Pubmed ID: 15466259
Omia ID: 807
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