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The bobtail or brachyury trait is caused by an autosomal dominant mutation in the T-box transcription factor T (TBXT) gene.
Working days 10
Specifiche
| Breeds | Australian Shepherd – Cane Pastore Australiano, Australian Stumpy Tail Cattle Dog – Bovaro australiano a coda corta, Bracco del Bourbonnais, Brittany (Épagneul breton), Cane da pastore croato, Cane da pastore dei Pirenei, Cane da pastore di Vallée, Danish-Svedish farmdog – cane da fattoria svedese, Mudi, Pastore americano nano (Miniature American Shepherd), Perro de agua Espagnol, Schipperkee, Swedish Vallhund (Vastgotaspets), Terrier brazileiro, Jack Russell Terrier, Welsh Corgi Pembroke |
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| Gene | |
| Organ | |
| specimen | Tampone, Sangue in EDTA, Sangue in Eparina, Seme, Tessuto |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informazioni generali
The bobtail or brachyury trait is caused by an autosomal dominant mutation in the T-box transcription factor T (TBXT) gene. The TBXT or T-gene encodes transcription factors that play critical roles in embryonic development, especially the tail and spine. A single copy of the mutation (heterozygous) causes the bobtail look, but two copies (homozygous mutant) disrupt development so severely that the embryo cannot survive. This makes the mutation homozygous lethal.
The tested mutation was originally discovered in the Pembroke Welsh Corgi, but also causes distinctive short tails in multiple other breeds, mainly sheepdogs and hunting breeds.
Caratteristiche cliniche
Dogs with one copy of the mutation have a naturally short or missing tail. If a puppy inherits two copies (homozygous mutant), it usually dies before birth due to the complete turn-off of the gene.
Informazioni aggiuntive
The T gene mutation is not present in all breeds of short-tailed dogs, and therefore another genetic factor is possible affecting the tail phenotype in for example Spaniels, Schnauzers and Rottweilers.
Riferimenti
Pubmed ID: 11252170
Omia ID: 975