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Intervertebral disc disease (IVDD) is a degenerative condition.
Working days 10
Specifiche
| Breeds | Bassotto Tedesco, Bichon Havanais, Bulldog francese – Bouledogue français, Cocker americano, Dandie Dinmont Terrier, Pechinese, Poodle (Miniature), Poodle (Toy), Springer Spaniel inglese, Basset Hound, Beagle, Cardigan Welsh Corgi, Cavalier King Charles Spaniel, Chesapeake Bay Retriever, Chihuahua, Chinese Crested Dog, Coton de Tulear, Jack Russell Terrier, Nova Scotia Duck Tolling Retriever, Scottish Terrier, Shih-Tzu |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informazioni generali
Intervertebral disc disease (IVDD) is a degenerative condition. The disease causes burstings into the spinal cord between the bones of the spinal column. The disorder is caused by a complex mutation, a FGF4 retrogene insertion, on chromosome 12.
Caratteristiche cliniche
Clinical features include abnormal walking, hunched back or neck with tense muscles, paralysis and reduced appetite and activity level.
Informazioni aggiuntive
The occurrence of this genetic variant in some breeds is high but it is known that not all dogs that carry the 12-FGF4RG variant will develop IVDD and vice versa. This suggests that this variant is not ‘the whole story’ and there are almost certainly additional lifestyle and/or genetic risk factors for IVDD that remain to be identified.
Riferimenti
Pubmed ID: 29073074
Omia ID: 157
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