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Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder found in the Dogue de Bordeaux, causing severe and painful thickening and cracking of the paw pads.
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Specifiche
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informazioni generali
Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder found in the Dogue de Bordeaux, causing severe and painful thickening and cracking of the paw pads. It is caused by a recessive mutation to the gene KRT16. It is also known as Focal Non-Epidermolytic Palmoplantar Keratoderma-1 (FNEPPK1).
Caratteristiche cliniche
Onset of HFH (aka FNEPPK1) can occur anywhere between 10 weeks and 1 year of age. The main symptom is a painful thickening of the paw pads, as well as the formation of cracks and/or lumpy growths of keratin. The cracks pose a risk of infection, which can in turn cause lameness.
Informazioni aggiuntive
Riferimenti
Pubmed ID: 25521457
Omia ID: 2088