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Von-Willebrand Disease (vWD) is a group of bleeding disorders caused by deficiency in the von Willebrand factor (vWF), which results in poorly functioning blood platelets and can lead to uncontrolled bleeding.
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Specifiche
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Tampone, Sangue in EDTA, Sangue in Eparina, Seme, Tessuto |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informazioni generali
Von-Willebrand Disease (vWD) is a group of bleeding disorders caused by deficiency in the von Willebrand factor (vWF), which results in poorly functioning blood platelets and can lead to uncontrolled bleeding. Type III (Type 3) vWD is the most severe form of the disease, and is caused by a recessive mutation to the gene vWF. This variant of Type III vWD is found in the ‘Kooikerhondje’. Related variants are also found in the Shetland Sheepdog and Scottish Terrier.
Caratteristiche cliniche
I cani affetti sono suscettibili a sanguinamento eccessivo e potenzialmente pericoloso per la vita dopo lesioni o interventi chirurgici e possono sviluppare sanguinamento spontaneo. L'analisi del sangue confermerà la mancanza di attività del fattore di von Willebrand.
Informazioni aggiuntive
Riferimenti
Pubmed ID: 9716162
Omia ID: 1058